Betrayal in Macbeth Essays - Characters In Macbeth, Free Essays

Betrayal in Macbeth Essays - Characters In Macbeth, Free Essays Ms Piersma ENG 3U October 28, 2015 Betrayal in Macbeth To the majority, betrayal is seen as contrary to our human nature. But, to some individuals betrayal is used as a tool to achieve goals. In William Shakespeares Macbeth characters display acts of betrayal in order to elevate themselves with no regard for themselves of others. First, the act of betrayal is perpetrated. Following, the individuals experience the consequences of their betrayal. Finally, others begin to feel the consequences of acts of betrayal not committed by them. In pursuit of power, people commit acts of betrayal which prove to have consequences for themselves and others Firstly, acts of betrayal are motivated by a desire for power. To begin, individuals commit acts of betrayal to ascend in status. For example, Macbeth betrays the king in order to become the new king. Paradoxically, Macbeth wants the throne but is appalled at the thought of killing the king. However, Macbeth is with the witches when the first two prophecies come true, which leads him to trust them and pursue the third prophecy relentlessly. Macbeth thinks immediately of murdering Duncan, which would create opportunity for the third prophecy, but is still horrified by his own idea. He says, why do I yield to that suggestion/ Whose horrid image doth unfix my hair/ And make my seated heart knock at my ribs/ Against the use of nature? (1.3.144-147). This clearly demonstrates that he understands that betrayal is evil. Additionally, when Macbeth leaves the banquet he is holding in Duncans honor to consider his conflict, he is interrupted by Lady Macbeth who convinces him that killing Dunca n is the best course of action. Macbeth says, I am settled and bend up/ Each corporal agent to this terrible feast (1.7.89-90). The quotations shown above show significant character development for Macbeth, and demonstrates how a desire for power leads to betrayal. Through the vivid imagery in the first quotation, through unfix my hair and make my seated heart knock at my ribs, it is clear that the thought of killing Duncan is hugely distressing for Macbeth. By saying Against the use of nature? Macbeth is explicitly acknowledging that to kill is completely unnatural. However, in the second quotation, it is obvious that Macbeth has decided to set aside his morality in pursuit of power. Macbeth suggests that he will strain every part of his body to kill the king, shown through Each corporal agent to this terrible feast. This resolve and dedication to killing Duncan shows that he is willing to do whatever must be done for him to become king, a stark contrast to the Macbeth whose heart leapt at the thought of killing another. This quotation clearly shows his commitment to the assassination of Duncan because of a desire for power. Secondly, individuals commit acts of betrayal to aid others in their ascent to power. Lady Macbeth betrays her identity as an archetypal woman in order to be able to counsel Macbeth in his pursuit of the throne. For example, in Macbeths castle in Inverness, Lady Macbeth is reading a letter that Macbeth has sent to tell her of the prophecies and their partial fulfillment. Lady Macbeth expresses her determination that the third prophecy will also come true. However, she believes that Macbeth is not capable of the action required, murdering Duncan. She calls on the spirits of darkness and evil to replace all of her feminine qualities with remorseless cruelty so that nothing will stand in the way of her evil plan. She says, Come, you spirits/ That tend on mortal thoughts, unsex me here, / And fill me, from the crown to the toe, top-full/ Of d irest cruelty! make thick my blood, / Stop up the access and passage to remorse, / That no compunctious visitings of nature/ Shake my fell purpose, nor keep peace between/ The effect and it! (1.5.43-50). The language she uses, specifically unsex me here,/ And fill me, from the crown to the toe, top-full/ Of direst cruelty implies that her womanhood impedes her from performing acts of violence and cruelty, which she associates with manliness. Lady Macbeth is willing to abandon her own sex and the presumptions associated with it in pursuit of power, which

Open University Malaysia †Graduate School Essay

Open University Malaysia – Graduate School Essay Free Online Research Papers I was born in Tawau, Sabah in 1972. I attended my primary and secondary school in Tawau, Sabah before continuing my education at Kolej Tunku Abdul Rahman, Kuala Lumpur in 1991. Upon graduation in 1996, I joined American International Assurance Company Ltd (AIA), Kuala Lumpur and was assigned to the Group Management Department as an Administration Executive. I have been working with AIA until June1999 and decided to left Kuala Lumpur after secured a job as Administrator in Expojuta Trading Sdn Bhd in Kota Kinabalu. In March 2002, I left Expojuta Trading Sdn Bhd and formed Bluetech Sdn Bhd, a company dealing with telecommunication products and services. In 2004, I bought over Pinnacle Communications Sdn Bhd and it become 100% fully own subsidiary of Bluetech Sdn Bhd. I was too concentrated and focus on my career at that time until I didn’t complete my full course under the Institute of Chartered Secretaries and Administrators. I was married in 2002 and had a child at the age of five now. During my semester break, I always strive to improve myself by taking various part time jobs in Kuala Lumpur as I believe that working experience gained from corporate world would be able to keep me in touch with the latest business trends and movements so as not to lag behind. In addition, I took up a correspondence course from Chung Hwa Correspondence School in Taiwan in 1994 and completed four subjects at their Department of Commerce. I was a student in The Institute of Chartered Secretaries Administrators since 1993 and completed 16 subjects. I take an active role in various societies in Kolej Tunku Abdul Rahman. I was elected as Vice Chairman in Sabah Sarawak Students Society in 1991/92. I provide many assistance to students especially those who are from Sabah and Sarawak in term of accommodation and transportation arrangement. I was a member of The Fund Raising Sub-Committee in Business Management Society in 1994/95. As a member of the Fund Raising Team, I learned how to work as a team and different method of fund raising. Being a young entrepreneur in order to stay competitive and responsive in today’s changing business world, I need to continually enhance my managerial skills and update my industrial knowledge. After well-thought out, I decided to pursue Master Of Business Administration programme (MBA) offer by Open University Malaysia. In order to gain entrance to the said programme through open entry, I was required to prepare a Portfolio Assessment. I believe that learning is a life long process and should not end after leaving school. After several years working in managerial level, I realized and concluded that I need integrating skills in my personality as well as in the work I do. I am confident that I can gain business decision making skills and turning my business concepts into realities through MBA programme. As the programme is flexible, I can study at my own pace without having to put my business or career on hold. I believe my working experience and former education do qualify me for the programme. I am self discipline, innovative, proactive and able to manage my time well. I proud myself as few local operators who providing encrypted two way radio communications network to users in Sabah since 2004. I plan to complete this programme in two years. I would like to see myself be more professional competence after two years. 2.0 CAREER AND ACADEMIC GOAL After graduation, I have been working with American International Assurance (AIA), the most trusted insurance company in Malaysia according to the survey conduct by Time and Fortune magazines. I have been assigned to lead Billing Section and supervise a team of five clerical staffs. I learned how to manage departmental backlog, administrative procedures and to ensure day to day operation of the Billing Section are productive and efficient. In 1997, I was awarded a special salary adjustment in recognition to my positive contributions to the Company. After returned to Sabah in July 1999, I worked as Administrator in a trading company where I can see a better picture of managing business as a whole. I learned marketing strategies, account and administration procedures as well as policy making. Being an Administrator, I worked with my team to complete four years company account within three months and get it ready for audit. I further introduced and implement computerize credit control s ystem in order to enhance debtors control and minimize bad debts. I always wanted to start my own business in technology related industries. After acquiring necessary business network, management and marketing skills, in 2001, I formed Bluetech Sdn Bhd, a company specialize in providing telecommunication products and services. I acquired Pinnacle Communications Sdn Bhd in 2004 as both Bluetech and Pinnacle Communications offering similar services in Sabah. I have three staffs work together with me to manage the company. I provide two way radio and walkie-talkie services to users in Sabah. I found that Global System for Mobile (GSM) network coverage in Sabah generally is still very limited especially in the remote area for example in Kuamut ,Pinangah and Tongod. As such, two way radio communication networks will able to close this gap and providing alternative way of communication to the users. I planned to further improve my existing two way radio communication network in Sabah to become multisite roaming in late 2008 in order to enhance network flexibility. As for oversea expansion program, I planned to set up a repeater station at Philiphine in year 2009 as we are geographically near to each other and necessary resources are readily available. Further more, the demand for alternative way of communication is huge and the market is still untap. I decided to take up Master Of Business Administration offer by OUM as I believe this programme will be able to enhance my strategic decision making skill and reinforce my organizational skills. With this programme, it will give me the competitive edge to go far in my future business development. I am confident that I will be able to complete this programme within two years. Research Papers on Open University Malaysia - Graduate School EssayAnalysis of Ebay Expanding into AsiaStandardized TestingLifes What IfsDefinition of Export QuotasTrailblazing by Eric AndersonInfluences of Socio-Economic Status of Married MalesThe Project Managment Office SystemRiordan Manufacturing Production PlanPersonal Experience with Teen PregnancyTwilight of the UAW

California Oil Spill Sparks State of Emergency Term Paper

California Oil Spill Sparks State of Emergency - Term Paper Example Oil spillages such as the BP Mexico Gulf catastrophe have normally been caused by unpredicted engineering failures. However, most of the failures have been attributed to unethical operations by the management of the responsible companies. Significant amounts of money were spent on disaster mitigation and response including compensations for loss of lives, financing cleanups and reconstruction of the damaged property (On-site clean-up of oil spillage, 2013). That solely focused on the California Oil Spillage that even sparked the State of Emergency. The State government of California parted allocated financial and other resources towards the management of the crisis. The paper explores the dangers posed by the threat and destruction that emanated from its occurrence. Engineering and ethical issues emanating from the disaster are discussed and the actual causes that might have resulted in its occurrence. Besides presenting an evaluation of the issues, the construct of this paper also e xplores the engineering efforts that were applied during the crisis to help prevent and reduce the adverse effects of the California Oil

Managing & Leading People Essay Example | Topics and Well Written Essays - 3000 words

Managing & Leading People - Essay Example The study has picked up the business environment in the South-Eastern Europe and has selected Mobiltel as the pivot for analyzing HR management policies and practices. Mobiltel stands to be one of the largest and most reliable Mobile Phone Service providers in Bulgaria, whose origins could be traced to the year 1994. Eventually, it was in September 1995 that Mobiltel was launched commercially in Bulgaria and since then the company has managed to assure a noticeable success and sustenance, while braving the diverse economic, political and organizational crisis and situations that came its way. The suitable, relevant and ever-evolving HRM practices at Mobiltel certainly played a central role in making it a business leader that enjoys the coveted honour of being amongst the top 10 Bulgarian companies. The raw material of the study is the HR management principles and practices adopted by Mobiltel, with an eye on the circumstances under which this was done. The conclusions of the study ar e based on the information gathered through a structured questionnaire and the secondary information culled out through the company sources and independent research. There is no denying the fact that East European corporations and especially the corporations of South-East European origin do face many challenges emanating from local and global circumstances, which do press on their ability to assure sustainability and market leadership. One simply cannot touch on the issue of South-East European business environment, without alluding to the political environment in the region that certainly has a direct impact on the available human resources and their management. The creation of new countries, courtesy the breaking of the erstwhile Eastern Block, the ongoing social fragmentation on the ethnic lines, the inability of the political authorities to

The Advancement of the Crusaders and the Church Research Paper

The Advancement of the Crusaders and the Church - Research Paper Example The crusades were a series of wars by Western European Christians to recapture the Holy Land from Muslims, which lasted till late 13th century1. Though there were various subtle factors behind the crusades, the first and the most noticeable one was the aggression by Islamic rulers. A look into the factors behind crusades makes it evident that they, in no way, advanced the cause of Christ because they were against the Christian worldview. The history of crusades As far back as in the third century, Christians used to visit the Hold Lands to see the places of Christ’s life. Though the place was conquered by Muslim rulers, pilgrimages continued without my disruption as Caliph Harun al-Rashid accommodated Christian pilgrims. However, the situation went wrong when the Egyptian ruler of Palestine in the 11th century, known as Hakim, started torturing the Christian pilgrims. He destroyed Constantine’s Church of the Holy Sepulcher and declared himself as God incarnate2. The Tur ks were advancing with enormous power. By 1050, they had a state in Persia and within five years, they reached Baghdad and up to Aegean in Anatolia. Soon Byzantine was defeated at Manzikert and a new sultanate was started at Nicaea. In the year 1071, Jerusalem became a part of the new Seljuk state of Syria. It was in this disorder and anarchy that General Alexius I Comnenus came to power in Byzantine. As already known, there was a split between the Eastern and Western churches. So, Pope Gregory VII found it a good opportunity to unite the Churches by spreading the holy war to Asia. So, he offered to send an army of western knights under his own leadership to Byzantine. Similarly, Pope Urban II offered military help to Byzantine against Turks. Pope Urban II pointed out in his speech at the Council of Clemont in 1095 the hardships faced by the Eastern Christians and the pilgrims to Jerusalem. He declared that God would assist those who would fight for their brothers. Another declarati on was that the sins of those who died in the work of God would be forgiven. Thus, enormous numbers of people joined the Crusade. Seeing the great Crusader armies, Turks surrendered Nicaea without a war. The crusaders advanced through Dorylaeum and soon, Edessa, a strategically important imperial city, was conquered and it became the first crusader state3. Soon, Jerusalem and Antioch were conquered by the Crusaders, and Baldwin of Edessa became the first king of Jerusalem. Within no time, the crusader states grew wealthy with the local resources. Admittedly, it was not the military order of the crusaders that helped them, but it was the lack of unity among the Muslims that allowed the crusader survival there. Soon, the Muslims united and a re-conquest was the result. Thus, in 1144, Edessa was captured by Muslims. At this point, St. Bernard preached the second crusade. As he managed to attract masses, King Louis VII of France and King Conrad III of Germany reached the East in what is called the Second Crusade. However, this time, the Crusade was destined to fail. First lf all, the local lords feared that the newcomers would take away their kingdoms and hence, the newcomers were in conflict with the local lords. Thus, the crusaders failed to conquer Damascus in 1149. The Muslim re-conquest continued undisturbed. Saladin of Egypt was a great ruler who managed to bring Syria and Mesopotamia under his control. By 1183, his brother was the ruler of

Small Dog Hotel In Guangzhou China Tourism Essay

Small Dog Hotel In Guangzhou China Tourism Essay Guangzhou is the largest city in south China. The wealth gap in the city is significant. Therefore, there is inexpensive labour available while high-end customers are willing to pay a profitable price for the services offered. The pet industry is booming. The dog population in the city has increased by 15% each year  [1]  . This makes dog boarding one of the most lucrative industries in the city Financially, it takes three months to reach positive net cash flow, and ROCE is negative in the first year, since the profit is negative, however, in the second year, the company will have substantial increase in profits, the profit will reach  ¥183,100. Description of Business Services Provided Dog Overnight Boarding: Providing overnight stay to dogs along with a complimentary dinner in the evening. Dog Day Play Group: Dogs are cared for during the day with play sessions in the morning and afternoon. Dog Taxi Service: Drivers pick-up dogs at 7 a.m., and brings them home in the evenings. This saves pet owners from the inconvenience of the hectic rush hour traffic. Special taxi booking is available at an additional fee. In-house shop offers dog products for long-term boarders. Owners can order dog treats over the phone using prepaid cards. Dogs will follow a structured daily schedule. Following each dogs stay, a complimentary report of the dog is provided to owners. Business Ownership The business will be a Limited Liability Company, as this can reduce tax liability in the long term. Company location Guangzhou city is in one of the wealthiest cities in south China. There is a increasing number of middle-class residents, and it is also close to the manufacturing towns where kennel equipment can be manufactured at a low cost. Woof Hotel is located in the northwest suburb of Guangzhou, near G105 motorway with good transport links. G105 is also linked to tourist resorts in the province where people take their pets on holiday. So, the company can advertise along the motorway to attract potential customers. The northwest suburb is a mountainous region away from residential areas, as this minimises noise from dogs barking. This particular location is surrounded by farmlands and allows for future expansion. The approximate commute time is 40 minutes from the city centre. Facilities and Staffing The maximum capacity is 100 dogs; each kennel measures 2 x 4m. There is a large fenced, grassed outdoor exercise area. There is a small kitchen for preparing dog foods. There reception area sells dog products, and there is also a customer lounge. Staff to dog ratio is 1:10. There are 24 hour surveillance cameras operating on-site to ensure the safety of dogs and staff. A burglar alarm will be installed to prevent dog thefts. Expansion Plan 2nd Year Increase kennel capacity by 50; Purchase agility equipment, a paddling pool and a sand pit for dogs to play in. 3rd Year Differentiate the kennels by building luxury suites as well as offer budget stays. Provide dog grooming service. 5th Year Introduce dog training and socialisation classes. Franchise opportunities become available. Build more Woof Hotels in other areas of the province. Marketing Market Needs The number of dogs in the city is growing by 15% each year; however, the pet service industry cannot keep up with the growth. People are unable to find satisfactory pet boarding kennels at reasonable rates. More professionals have pets. However, most people dont have time to adequately care for their dogs for 365 days a year. Finally, dogs arent allowed on any public transport anywhere in China, which makes it difficult for people to travel with their pets. SWOT Analysis Strength Weakness Management team has expertise in starting a small business Director has seen many successful pet boarding business overseas Being the first dog kennel can make the company the industry leader The idea of boarding kennel has not been tried and tested in the country Team leaders have no previous experience in pet industry Lack of skilled workers Opportunities Threats The pet industry is booming There is increasing demand for boarding kennel The satisfaction rate for the service offered by competitors is low Competitors may enter this lucrative market in a few years, this may decrease the market share of the company Competition At the moment, there are very few direct competitors boarding kennels. The indirect competitors are: Private Veterinary Surgery: These surgeries are small and the housing is in poor condition. As sick dogs are coming in to see the vet and boarders are placed in a cage along with sick dogs. The vet is not responsible if a healthy dog boarder falls ill. The risk being the cost for treatment in case the pet contracts a virus is extremely high. The vet charges a high rate for boarding fees. Home boarding: There are currently a small number of people offering home boarding. However, they are not regulated; Customers do not know their backgrounds therefore difficult to establish reliability. It is predicted there will be an increase in the number of both domestic and overseas competitors in the future which will invest in this lucrative market. Differential advantage Woof house is aimed toward middle class dog owners, since positioning the company in the middle class makes it easier to move up or down the market. The industry is new; demand from each segment of the consumer market is unknown. In the expansion plan, the company will introduce luxury and budget stays to accommodate customers needs. Promotional Plan A lot will be invested in advertising during the first year, including: Sign posts along the motorways G105. Leaflet distribution: either by hiring commissioned people wearing company tee-shirts to distribute the leaflets in streets, Discounts offered during low seasons Advertising in partnerships with pet shops, with free taster boarding vouchers available The van transporting dogs with the company logo on will be self-marketing when driving in the city Market Research The director has conducted desk research on www.goumin.com , a popular networking site for dog owners. The main issues facing them include lack of boarding kennel in the city; no transport which allows pets on hence restricts their movement, and expensive vet fees. The demand for boarding kennel is very high, yet there isnt any available at the moment. Since response rate on forums is high. The director has posted a survey on the website (see appendix), in order to find out the monthly spending by dog owners and decide the pricing structure of Woof Hotel. Also, Woof Hotel will also use questionnaire to get feedbacks from owners after their dogs have stayed in the hotel, in return they are given discount towards their next stay. Customers and Pricing Woof Hotel is targeted toward middle income people; the rate is set to be low at  ¥50 per stay in the first year in order to attract customers. However, the vets charge the same rate  ¥50 at a monopolized price with poor service standards dogs in cages all day with no exercises at all. The consumer is predicted to be price insensitive, they can accept price increase if it matches the service provided. Moreover Woof Hotels rates are at a reasonable level. Service Operations Premises and Vehicles The cost of purchasing land is high, and some land isnt available for purchase by the government. Therefore, Woof Hotel will rent the site. Since the company is located in the suburbs and rural areas, the cost of renting land for agricultural purposes is low; the rent per m2 is estimated to be 95% less than in the city centre. IT The Woof Hotels personalised webpage needs to be set-up; there is a cost to purchase the domain. The Internet is increasingly popular today. It also serves as an advertisement of Woof Hotel. The receptionist will be trained to answer all the queries regarding to staying in Woof hotel. Insurance Currently, there is few insurance providers for pets in China. The insurance cover for business start-up is expensive; Therefore, Woof Hotel will not purchase any insurance during its first two years. However it may decide to do so in the future, depending on the circumstances. Local Regulations Currently there are no laws aimed specifically at dogs. Although a compulsory Dog ID tag was introduced in 2009  [2]  , many dogs still remain unregistered. Some unregistered dogs dont have vaccination certificate even they have been vaccinated. This is the main issue facing Woof Hotel, there is a risk of other dogs contracting the virus, however these owners represent a large proportion of potential clients. Management and organisation Team Leaders Lin Zhang Financial Director A Mathematics graduate at University of Warwick, also pursuing a MSc in Finance A life- long dog lover, having raised puppies and have first-hand experience with caring for dogs, good knowledge on basic dog care Very business- minded and passionate about starting a pet care business Multilingual, able to travel abroad to visit and study from other partner boarding establishments. David Zhang Managing Director Experienced as the facility manager at a multinational company for over 10 years Several years of experience starting and running small businesses Have excellent local knowledge and business networks in the area. Team Members Staff A Receptionist Customer Service: answering customers enquiries Staff B and C Dog Carer Responsible for looking after dogs and supervising their plays Staff D Driver Responsible for transporting dogs to and from Woof Hotel Responsible for transporting dog foods and other necessities for Woof Hotel Staff E Gardener and Cleaner Maintaining the landscape and garden of the Woof hotel Clean dog kennels daily Remuneration In the beginning, Woof Hotel will hire low cost labour workers. The market price for an unskilled worker is approximately  ¥2000 per month. In the future, Woof Hotel may recruit skilled workers such as graduates from the local veterinary college. The wage cost will increase to approximately  ¥3000 per month, but Woof Hotel hope to retain these skilled workers to increase customer satisfaction. Recruitment The recruitment will be advertised. As there are many migrant workers in the city, unskilled labours are easy to recruit. Unfortunately, there is a loophole in Chinas laws. People with a history of animal abuse do not have criminal records. There is a risk that staff recruited may abuse animals. In such cases, the person will be dismissed immediately. The presence of surveillance cameras ensures the welfare of all our dogs. Financial Reports PROFIT AND LOSS ACCOUNT for Woof Hotel Unit:  ¥ ( ¥1 =  £0.1 ) Year 1 Price per Dog per day 50 Average No. of Dogs 35 Gross Sales Daily 1750 Gross Sales Annually (365 Days) 638,750 Sales Tax (6%) 38325 Gross Profit 600,425 OVERHEADS Wages 200,000 Rents 60,000 Utility Bills 70,000 Insurances 0 Dog food 150,000 Staff Vaccination and expenses 1,500 Telephone 2,400 Professional fees and recruitment 24,000 Transport 60,000 Advertising 200,000 Gardening and Cleaning 25,000 Sundries 50,000 TOTAL OVERHEADS 842,900 Net Profit(Loss) Before Tax -242,475 Corporation Tax (20%) 0 Profit for the year -242,475 PASTE CASH FLOW STATEMENT HERE BALANCE SHEET Unit:  ¥ ( ¥1 =  £0.1 ) Year 1 ASSETS Fixed Assets Property-kennels and exercise area 100,000 Property- office staff accommodation 80,000 EM 50,000 Equipment 50,000 Vehicle 120,000 TOTAL FIXED ASSETS 400,000 Current Assets Cash 843,100 Debtors 0 TOTAL CURRENT ASSETS 843,100 TOTAL ASSETS 1,243,100 LIABILITIES Loans 0 Current Liabilities 0 Tax Payable 0 Overdraft 0 Creditors 0 TOTAL LIABILITIES 0 CAPITAL ACCOUNT Capital 1,485,575 Reserves (PL from Yr 1) -242,475 TOTAL CAPITAL 1,243,100 Analysis Gross Profit Margin = Gross Profit / Revenue x100 Year 1: 600,425/638,750 = 94.4% Year 2: 1,441,020/1,533,000 = 94% Break Even Units = Total Overheads / (Price of Product Direct Cost of Product) Year 1:  ¥842,900 / 50 = 16,858 units Year 2:  ¥1,212,000 / 60 = 20,200 units Break Even Sales = Total Overheads /Gross Profit Margin x 100 Year 1:  ¥842,900/94.5 =  ¥891,957 Year 2:  ¥ 1,212,000/94 =  ¥12,893 ROCE = Profit before tax/(Capital Reserve+ long term loans) x 100 Year 1: -242,475/1,243,100 = -19.5% Year 2: 183,216/ 6,700,037= 2.7% Assumptions The utility bill and rents are paid every month There is no depreciation in the first two years Dog pays on arrival; the company has no borrowings. Therefore no debtors or creditors. Utility bill: air-conditioner is used in summer; no heater is needed in winter Commentary The number of holidays each month is likely to coincide with the income (see appendix for more details). Since this industry is relative new, the financial reports cannot give a reliable estimate, how people will respond to the business is uncertain, the actual number of dogs may vary. This will affect many figures in the financial reports. It takes approximately three weeks to reach positive cash flow. There is no gearing ratio since the company doesnt have any loans. ROCE is negative in the first year since the company is making a loss; however, the company has substantial increase in profit in the second year. Appendices Currency In the business plan, the local currency Chinese Yuan is used, its exchange rate to British Pound is  [3]  :  ¥1 =  £0.096 or  £1 =  ¥10.4 Proposed location of Woof Hotel on Google map Indicated by the arrow is the proposed location of Woof Hotel, it is close to motorways G105; The label A is the city centre., Woof Hotel has good transport links, the driving time is 30 minutes to city centre. Dog ownership Statistics in Guangzhou City The number of pet dogs in Guangzhou has increased rapidly since 1995 by official statistics  [4]  ; it is going to increase by 15% each year, which coincides with the economy boom, as peoples income increases, they are more willing to invest in their pets. Monthly Spending by Dog owners A survey was conducted on http://bbs.goumin.com/forum-24-1.html, 32 people have responded, their average spending is calculated to be:  ¥1,159; with a standard deviation of  ¥ 563. However, this sample is biased; also the spending is likely to double or even triple if the animal needs to veterinary attention, which has not been taken into account. Statistics of Holidays in China  [5]   The chart shows the statistics of the number of bank holidays per month in China, which is likely to coincide with the profitability of Woof Hotel, however, school holidays in February, July and September which are also high seasons have not been included when families are most likely to travel. Thus the high season will be from January to February and from May to August. The low seasons will be March, April and from September to December. What the paper says Extract from financial express http://www.financialexpress.com/news/pet-industry-has-never-had-it-so-good-in-china/201045/, titled pet industry has never had it so good in China: In some parts of the country, ownership is seen as a must-have accessory for the well-off The country has 100 million dogs in 2007 and is expected to reach 150 million by 2010. The market potential is expected to reach $5 billion by 2010. The recent pet-boom has given birth to a new economics sector in its own right the pet economy sector. In pet food industry alone, the compounded growth rate is averaging 30% per year.

Meacham v. Knolls Atomic Power Laboratory Essay example -- Anti Discri

Meacham v. Knolls Atomic Power Laboratory The "2nd U.S. Circuit Court of Appeals" held that those business practices that have had a disparate impact effect on the older workers are now considered to be actionable under one national anti-discrimination law (Hamblett, 2004). The case does reaffirm a second Circuit precedent that had been set but which is at odds with what a majority of federal courts have held. The appeals court supported the idea that a layoff plan had been properly brought under the The Age Discrimination in Employment Act of 1967 (ADEA) although the company did not have the intention of discriminating. The case Meacham v. Knolls Atomic Power Laboratory did in fact uphold the jury's findings that employees who are on the older side had lost their jobs through a layoff plan. This discrimination was unintentional. However, the policy did have an impact that was deemed discriminatory and the firm could have reached its goals through a different method that would not effectively discriminate. The reason for the suit had to do with the fact that thirty of thirty-one people who were laid off were over the age of forty. There were 26 plaintiffs who did go to trial while some of the others settled with the company on their own. In the end, the jury awarded plaintiffs a total award of $4.2. The case was appealed and at the time, Knolls argued that the law really does not allow disparate impact claims, citing Hazen Paper Co. v. Biggins, 507 U.S. 604 (1993), where a claim involved disparate treatment and what was needed was proof of intentional discrimination. The Court claims that the Ha zen Paper Court had not resolved the appropriate use of ADEA in terms of disparate impact. It was further stated that the decisions to come from other circuits do not necessarily overrule prior cases. The idea that disparate impact claims may not be allowed under ADEA is therefore rejected. It seems that the major issue here is whether or not one can use age as a factor in terms of discrimination when the discrimination was not intentional. If for example it turns out that the people who are laid off are over the age of 40, even though no malicious intent is discovered, it still may be construed as age discrimination. This issue has been somewhat controversial for some time, as most litigants in age discrimination lawsuits realize that they ... ...g went to the fact that even though the business did not purposely discriminate, it did in fact due to a policy that is discriminatory in nature. In other words, the true reason for the firing was directly related to substance abuse. Although the employee was technically not let go due to the abuse specifically, the fact that this occurred in fact is enough to render the policy unfair. I feel that this law provides great value to my workplace as, it protects those who have made mistakes at the workplace due to a disability. In this case it was substance abuse, but the same concept could be applied to other conditions that alter behavior. References Hamblett, M. (2004, August 26). 2nd Circuit: Impact of Employer Acts Grounds for Suit: Court rules on disparate impact theory of recovery. New York Law Journal. Retrieved April 4, 2005 from http://www.law.com/jsp/article.jsp?id=1090180422885 SUPREME COURT OF THE UNITED STATES RAYTHEON CO. v. HERNANDEZ: CERTIORARI TO THE UNITED STATES COURT OF APPEALS FOR THE NINTH CIRCUIT. No. 02—749. Argued October 8, 2003–Decided April 2, 2003. Retrieved April 4, 2005 from http://supct.law.cornell.edu/supct/html/02-749.ZS.html

Education Acts and Reports Essay

Integration of the various racial and ethnic groups, the central aim of the 1 Malaysia concept, had always been the primary concern of the governments’ education policy since Independence in 1957. In fact the Razak education report of 1956 and the Rahman Talib report of 1960 had delineated clear guidelines and emphasise national integration. Compare and contrast out the aims and provision of Barnes Report (1950), Fenn-Wu Report (1951), the Razak Report (1956) and the Rahman Talib Report (1960). After World War Two, the education system in Malaya was pretty much in shambles, and until Malaya achieved her independence in 1957, much had to be done to map out a new education system for the nation. Efforts began with the introduction of a new, national education system with English as the one and only medium of instruction, but eventually, an education system was formed in which Malay became the main medium of instruction. In 1949, a Central Advisory Committee on Education was set up to aid the government in deciding on the best form of education system, which could be implemented in Malaya, to be the catalyst in fostering national unity. In 1950, the Barnes Committee came out with the Barnes Report, which proposed that all primary vernacular schools maintain one single standard and become national schools using the same syllabus but bilingual languages, which were Malay and English. Secondary schools, however, had to maintain English as their mode of instruction. One year later in 1951, there was the Fenn-Wu Report, which whole-heartedly supported the formation of a national education system, but felt that the Chinese-medium schools should be maintained. Their argument was that the country could still achieve unity although there was diversity in the medium of instruction. It was only in 1952 that the Education Ordinance was passed, based on the Barnes Report. This did not garner good response from the Chinese and Indians, who protested the abolition of their mother tongues as one of the mediums of instruction. Due to the failing economy and shortage of trained teachers for the national schools, however, the Education Ordinance of 1952 was not fully implemented. Three years later in 1955, another committee was formed, this time chaired by Dato’ Abdul Razak Hussein and it was given the task of reviewing the education system of Malaya. The committee received 151 memorandums from individuals, public bodies and associations. After much deliberation, the Razak Committee proposed, one year later, the following: †¢ The education system should comprise two types of primary school – standard primary schools that use Malay as their medium of instruction, and standard-type primary schools that use either Kuo-Yu or Tamil or English as the medium of instruction. Both these schools, however, would rely on a common syllabus. †¢ Both types of primary school should enforce Malay as a compulsory subject. †¢ All National Secondary Schools should use a common syllabus and examination and enforce Malay and English as their compulsory subjects. †¢ All teachers, regardless of which school they would eventually teach at, should be trained with a common syllabus in teachers’ training colleges. In 1960, the Rahman Talib review committee was commissioned to study the Razak Report, with the aim of strengthening its implementation and emphasizing the use of Malay as the medium of instruction. The Rahman Talib Report became the basis for the Education Act 1961, which was subsequently passed by the Parliament. Three main components were maintained: i. A common schooling system for all races; ii. The national language as the main medium of instruction for all level of schooling; and iii. A common national-based school curriculum and examination. The 1996 Education Act was formulated as a continuation modernisation of the 1961 Education Act. Describe the main provision of the 1996 Education Act and their application in the education system and in the schools. The Razak Report can be regarded as the foundation for the development of the National Education System used. The main issues in the National Education were: i) The desire to form one National Education System for all races; ii) To make the Malay language the main medium of instruction; iii) To establish a curriculum orientated towards the local environment through the formulation of a common education syllabus with similar contents; and iv) Strengthen the National Education System for all students in it. The development of the formation of the Education Act was continued in order to resolve several requests voiced by the different races in Malaysia and to improve on suggestions recommended in the Razak Report. This was known as the Rahman Talib Report (1960) and it became the basis for the formation of the 1961 Education Act. Amongst the changes and amendments made to the Razak Report were: primary education was free; primary schools became national schools and national-type schools; advanced education was extended to 15 years of age; students advanced to the next standard automatically; Islamic studies for students when there were not less than 15 students; and Moral education was given due attention. After the 1960 Abdul Rahman Talib Report, there come more reports for example  the Hussien Onn Report (1971) and 1979 Mahathir Report. Both these Reports were done to re-examine the Country’s Education Policy which was based on the Razak and Rahman Talib Reports. The 1996 Education Act was formulated as a continuation and modernization of the 1961 Education Act. The aim of the 1996 Education Act was towards strengthening the National Education System for the next generation in line with the needs and aspirations of the country to make Malaysia an international centre for educational excellence. Even though the Education Act 1996 was a new legislation, it reflected a continuity of the wishes and policies of the existing education system. It was formed along the main recommendations of the Razak Report, 1956 which was the basis of the National Education Policy till then. The new Act also continued some of the relevant suggestions from the Education Act 1961. The objective for drafting the laws (Education Act 1996) was to widen the scope and introduce legislation on education. Clause 152 of the Malaysian Constitution has positioned the Malay Language as the National Language to ensure unity of its population. The National Education Philosophy was made a basis of the National Education Act formulated after taking into account the views and aspirations of all sectors. The aim of the Education system in Malaysia was formulated based on the objective found in the National Ideology, National Education Policy and New Economic Policy (NEP). Among the objectives of the Education System in Malaysia are: i) Production of quality education; ii) Production of educated and skilled students; iii) Production of unified community; iv) Social community development; v) Production of quality workforce; vi) Economic production, especially in rural areas; vii) Formation of responsible and commited citizens in a democratic country; viii) Restructuring of socio-economic structure of the population as stated in the New Economic Policy (NEP); and ix) Eradication of poverty. By the Education Act, the concept of the National Education System was improved with the inclusion of all levels of schooling from pre-school to higher education, covering all school categories which is government, government-assisted and public schools. The position of National Language was enhanced with its allocation as the main medium of instruction in the National Education System. This was further strengthened when the language was made a compulsory subject at all schools and educational institutions. The Clauses 152 of the Malaysian Constitution had positioned the Malay Language as a National Language to ensure racial unity. The position of the Malay Language became even more secured when the National Language Act was passed in 1967. Beginning 1970, the medium of instruction in English primary schools were changed to the National Language in stages. Several measures were taken to develop the Malay Language including the establishment of the Dewan Bahasa dan Pustaka (DBP) in 1956, the launch of â€Å"Language Week† and â€Å" Language Month† to encourage the use of the Malay Language and the launce of the â€Å"Bahasa Jiwa Bangsa† slogan in 1960. Other methods included the establishment of secondary schools which used the Malay Language as a medium of instruction, for example in Alam Shah School, Sri Puteri School and Sultan Abdul Halim School. The curriculum for all types and categories of schools were coordinated in line with the country’s need, when the usage of the National Curriculum allocated in the Education Act 1996 became compulsory for all. Students from all types and categories of schools were prepared to sit for examination conducted by the Government and as a result, it simplified the usage of a common evaluation or appraisal method on the achievement of students from schools in the country. Religious Studies were extended to include Muslim students from all categories of schools including public schools and strengthened by making the subject one of the core subjects in schools. With the existence of allocation that allowing the Minister of Education to establish and manage kindergarten, the less fortunate from the rural areas were given a chance to get pre-school education which is considered a good basis when starting primary education. The quality of education programmes at all kindergartens could be improved as it is compulsory for all these kindergarten to use the Pre-school Curriculum Guidelines produced by the Education Ministry. In line with the efforts to culturalize the education of science and technology, technical education were improved in secondary technical schools and polytechnic institutions. The Education Act 1996, made it easier for the status of vocational schools to be upgraded to that of technical schools, while polytechnic institutions can conduct co-operative programmes with any institutions, agencies or industrial organizations to manage technical or vocational courses or training programmes, including exchange programmes. Polytechnic institutions are allowed to conduct twinning programmes for diploma and degree courses with Higher Education Institutions either locally or internationally. Teachers’ training was strengthened with the allocation that allowed the Ministry of Education to organize Teachers’ Education Programmes at certificate, diploma and degree levels in pairs. Private education was developed in a more systematic manner with specific allocations. Attention was also given to vocational education for this particular group of students. However, intensive vocational training, for example for blind students was given after they left school. The most important component in the special mixed education was the resource teachers who were responsible not only for teaching handicapped students but also assisting the normal teachers, build and prepare teaching and learning materials as well as provide counseling service for the students. Realising that Malaysia is a multi-racial country, and based on political discussions conducted by previous leaders, the Education Act 1996 took into consideration the rights of all races by maintaining the status quo of national type of primary schools and 60 private Chinese schools. Apart from that, the United Examination carried out by these schools as well as the conforming schools and mission schools, the Board of Supervisor was also maintained. The Education Act 1996 also allocated for the teaching of languages or natives living in the country if it is deemed acceptable and practical. Religious classes like bible classes do not have to be registered under the 1996 Education Act. The Malaysia Qualification Agency (MQA) was established on the 1st of November 2007 with the enactment of the Malaysia Qualification Agency Act (Act 679). As a result MQA takes on the role of LAN as well as playing a more comprehensive role as stated in the Act. What are the main features of the Malaysia Qualification Agency? In what ways is the Agency playing a bigger role than the defunct National Accreditation Board (LAN)? Please refer to the MQA website for more information http://www. mqa. gov. my. The National Accreditation Board or Lembaga Akreditasi Negara (LAN) was established in 1996 under the Parliament Act and was the national quality assurance agency for private higher educational institutions. Meanwhile, the quality assurance divisions under the Ministry of Higher Education supervised the quality of public universities, polytechnics and public community colleges. On 1st of November 2007, a new agency Malaysian Qualification Agency (MQA) was established under a new education legislation the Malaysian Qualification Act 2007. This new Malaysian Qualification Agency replace the following agency: * Lembaga Akreditasi Negara (established under Act 556), for private higher educational institutions * The Quality Assurance Division of MOHE, for public universities * The Quality Assurance Division of MOHE, for polytechnics & community colleges MQA comes under the responsibility of the Ministry of Higher Education (MOHE). MQA acted as a national body to implement the national framework known as the Malaysian Qualifications Framework (MQF), to accredit higher educational qualifications, to regulate the quality of higher education providers, to establish and maintain the Malaysian Qualification Register. The establishment of a new entity which merges National Accreditation Board (LAN) and the Quality Assurance Division, Ministry of Higher Education (QAD) was approved by the Government on 21st December 2005. This entity is responsible for quality assurance of higher education for both the public and the private sectors. The main role of the MQA is to implement the Malaysian Qualification Framework (MQF) as a basis for quality assurance of higher education and as the reference point for the criteria and standards for national qualifications. The MQA is responsible for monitoring and overseeing the quality assurance practices and accreditation of national higher education. With the vision to be a credible and internationally recognized higher education quality assurance body and the mission to inspire the confidence of its stakeholders through best practices, the MQA is set to chart new boundaries in higher education quality assurance. The MQA Act is designed to promote the dynamic growth of higher education and the portability of Malaysian qualifications. It should inspire the confidence of parents, students, employers, both local and international in the standards of qualifications and quality of their delivery. The MQA Act 2007 comprises the following 16 parts: Part I: Preliminary definitions Part II: Malaysian Qualification Agency Part III: Malaysian Qualification Council Part IV: Provisions Relating to Employees Part V: Financial Provisions Part VI: Malaysian Qualification Framework Part VII: Provisional Accreditation Part VIII: Evaluation of other Qualifications Part X: Institutional Audit Part XI: National Qualification Register Part XII: Appeals Part XIII: Enforcement and Investigation Part XIV: Offences and Penalties Part XV: Miscellaneous Part XVI: Repeal, Savings and Transitional The 16 parts of MQA Act include the provision for: * The establishment of MQA as the agency with overarching responsibility for assuring the quality of all post secondary programmes and qualifications provided by higher education providers in the country. * The establishment of the Malaysian Qualification Framework (MQF). * Provisional accreditation as the initial process towards accreditation. * Accreditation that takes into consideration the diversity of higher education in Malaysia : local program under MQF, foreign programmes including collaborative arrangements, distance and e-learning, professional programmes and skill qualifications. * Registration of qualifications from self-accrediting institutions. * Recognition of prior learning and experience and credit transfers. * The Malaysian Qualifications Register (MQR) as the national reference point for all qualification that have been accredited. As a quality assurance body, the functions of MQA are: * To implement MQF as a reference point for Malaysian qualification. * To develop standards and criteria and all other relevant instruments as national references for the conferment of awards with the cooperation of stakeholders. * To quality assure higher education institutions and programmes. * To accredits courses that fulfill the set criteria and standards. * To facilitate the recognition and articulation of qualifications. * To maintain the Malaysian Qualification Register (MQR). The establishment of the MQA and the implementation of the MQF will benefit national higher education and the development of human capital. In the Quality Assurance System, MQA has developed a code of practice on criteria and standards for higher education in Malaysia. This code of practice is benchmarked against international good practices and nationally accepted by stakeholders through various consultations. The code provides a guideline of general requirements in the following areas: * Vision, mission and learning outcomes. * Curriculum design and delivery. * Student selection and support services. * Assessment of students * Academic staff * Educational resources * Program monitoring and review. * Leadership, governance and administration. * Continuous quality improvement. In general, MQA quality assures programmes through two distinct processes: * Provisional Accreditation – this is initial process which will help higher education providers to achieve the accreditation by enhancing the standard and quality set in the provisional accreditation evaluation. * Accreditation – this is a formal recognition that the certificates, diplomas or degrees awarded by higher education institutions are in accordance with the set standards. The MQA Act 2007 also provides for the conferment of a self accrediting status to mature higher education institutions that have well established internal quality assurance mechanisms. To be so conferred, the higher education institution needs to undergo an institutional audit, and if successful, all qualifications it offers will be automatically registered in the MQR. The processes above are further supported by continuous monitoring to ensure the programmes offered by the institution are always quality assured. Further, nine criteria have been benchmarked as international best practice, which forms the basis of the accreditation assessment. Accreditation will be the highest status in quality assessment done by MQA. It will be the guarantee given by MQA to all stakeholders of higher education which include students, parents, employers, etc. that programmes accredited by MQA are quality programmes. Once the courses of study are accredited, the accreditation status will remain for as long as the institution can meet the framework requirements and QA standard and criteria as well as institutional mission under the MQA’s Institutional Audit. RUJUKAN Akta Pendidikan 1961. (1984). International Law Book Service. Kuala Lumpur Akta Pendidikan 1996. (1998). International Law Book Service. Kuala Lumpur Federation of Malaya. (1951). Report of the Committee on Malay Education. Kuala Lumpur: Government Press. Tie Fatt Hee (2000). Undang-undang Pendidikan di Malaysia. Kuala Lumpur: Fajar Bakti.

List of Poets Laureate of the U.S.A.

List of Poets Laureate of the U.S.A. Who are all the poets who have served the Library of Congress as Consultant (the old title) or Poet Laureate Consultant (the new title)? Learn more about the lives and works of these distinguished artists through the resources listed below. 1937-1949 Joseph Auslander 1937-41: His sonnet, â€Å"To My Despoiler†Allen Tate 1943-44: His essay on writing poetry, â€Å"Narcissus As Narcissus†Robert Penn Warren 1944-45Louise Bogan 1945-46Karl Shapiro 1946-47Robert Lowell 1947-48Leonie Adams 1948-49Elizabeth Bishop 1949-50 1950s Conrad Aiken 1950-52: First to serve two termsWilliam Carlos Williams: Appointed to serve two terms in 1952 but did not serve.Randall Jarrell 1957-58Robert Frost 1958-59Richard Eberhart 1959-61: â€Å"A Student’s Memories of Richard Eberhart,† by David Graham 1960s Louis Untermeyer 1961-63: His poems â€Å"Prayer,† â€Å"Summons† and â€Å"On the Birth of a Child† and â€Å"Reveille†Howard Nemerov 1963-64Reed Whittemore 1964-65Stephen Spender 1965-66James Dickey 1966-68William Jay Smith 1968-70: His â€Å"Epigrams† 1970s William Stafford 1970-71Josephine Jacobsen 1971-73Daniel Hoffman 1973-74Stanley Kunitz 1974-76Robert Hayden 1976-78William Meredith 1978-80 1980s Maxine Kumin 1981-82Anthony Hecht 1982-84Robert Fitzgerald 1984-85: Appointed and served in a health-limited capacity, but did not come to the Library of CongressReed Whittemore 1984-85: Interim Consultant in Poetry  Gwendolyn Brooks 1985-86  Robert Penn Warren 1986-87: First to be designated Poet Laureate Consultant in PoetryRichard Wilbur 1987-88Howard Nemerov 1988-90 1990s Mark Strand 1990-91Joseph Brodsky 1991-92Mona Van Duyn 1992-93Rita Dove 1993-95: Her poem, â€Å"Lady Freedom Among Us†Robert Hass 1995-97:  Poems, translations, bibliography and articles about Hass’ workRobert Pinsky 1997-2000​:  His Favorite Poem Project 2000s Stanley Kunitz 2000-2001​Billy Collins 2001-2003: His Poetry 180 Project to bring poetry into American high schoolsLouise Glà ¼ck 2003-2004Ted Kooser 2004-2005: Excerpt from his book, The Poetry Home Repair Manual, Practical Advice for Beginning PoetsDonald Hall 2006-2007: His reading of, â€Å"Poetry Across the Atlantic,† in a historic joint reading with U.S. Poet Laureate Hall and UK Poet Laureate Andrew MotionCharles Simic 2007-2008Kay Ryan 2008-2010:  Her poems, audio readings and podcasts 2010s W.S. Merwin 2010-2011Philip Levine 2011-2012Natasha Trethewey 2012-

Tuberous Sclerosis Complex (TSC)

Tuberous Sclerosis Complex (TSC) Free Online Research Papers A French physician more than 100 years ago first identified a disorder-once known as epiloia or Bourneville’s disease. Today it’s known as Tuberous sclerosis also called tuberous sclerosis complex (TSC). TSC is a rare, multi-system genetic disease that causes benign tumors to grow in the brain and on other vital organs such as kidneys, heart, eyes, lungs , and the skin. It commonly affects the central nervous system and results in a combination of symptoms including seizures, developmental delay, behavioral problems, skin abnormalities, and kidney disease. I will look at the following: 1. Clinical manifestations 2. Diagnostic 3. Genetics of TSC 4. Signs and symptoms 5. Psychopharmacology in children with TS The manifestation of TSC is a disease that affects multiple organs such as skin, kidneys, brain, heart, eyes, lungs, teeth as well as other organ systems. However in most individuals the disease affects only some of the organs. TSC may present at birth, but signs of the disorder may take some time to develop. At least two children born each year will have TSC. Current estimates place TSC affected births at one in 6,000, nearly 1 million people worldwide and, approximately 50,000 in the Untied States. As a result, TSC is frequently unrecognized and misdiagnosed for years. The severity of TSC can range from mild skin abnormalities to, in severe cases, mental retardation and renal failure. Many TSC manifestations also develop later in life. Most individuals who are mildly affected lead active and productive lives. TSC is a life long disease and individuals should receive continuous follow-up care. In most cases the first clue to recognizing TSC is the presence of seizures or delayed development. In other cases the first sign might be white patched on the skin. Careful clinical exam in combination with CT or MRI of the brain may show tubers in the brain, and an ultra sound of the heart, liver, kidney scan show tumors there In July 1998 the Tuberous Sclerosis Alliance, convened a consensus conference of international experts to review the literature and the status of knowledge and research about TSC. One of the consensus panels developed a revised scheme for the TSC diagnostic criteria based on new clinical and molecular genetic studies. The new diagnostic criteria eliminated any single finding as specifically distinctive or characteristic of the disorder. Cortical tubers were believed to be pathognomonic of TSC. Evidence now suggests that radio graphic brain imaging and histologic studies are unable to distinguish these tubers from isolated cortical dysplasia. Subependymal giant cell astrocytomas and subependymal nodules can be distinguished from cortical tubers and from each other. The two subependymal lesions have a histologic and radiographic appearance that differs from the cortical tuber, whereas the giant cell astrocytomas is the only on that tends to enlarge. An important tool in diagnosing is its dermatologic manifestation, which comprises four major and one minor feature of TSC. Hypomelanotic macules are considered a new grouping, whereas the histologically similar forehead plaque, facial angiofibroma, and renal or other retinal hamartomas, are considered to major features used in diagnosis. Liver, spleen, rectal, or other lesions preferably Histologically confirmed hamartomatous lesions constitute minor features. TSC is caused by defects, or mutations, on two genes-TSC1 and TSC2. Only one gene needs to be affected for TSC to be present. The TSC1 gene is on chromosome 9 and produces a protein called hamartin. The TSC2 gene is on chromosome 16 and produces the protein tuberin. Scientists believe these proteins act as tumor growth suppressors, agents that regulate cell proliferation. Some individuals may inherit the disorder from a parent; most cases occur as spontaneous mutations. In other cases, TSC is an autosomal dominates disorder. Which means only one parent needs to have the gene, and each child has a 50% chance of developing the disorder. Some individuals acquire TSC through gonadal mosaicism. Approximately 33%, or 1/3, of the people with TSC inherits it from a parent who has it. Signs of discovery vary depending on which system and which organs are involved. Kidney problems such as cysts and angioyolipomas occur in an estimated 40 to 80 percent of individuals with TSC, usually occurring between ages 20 and 30. Three types of tumors are associated with TSC: cortical tubers, generally form on the surface of the brain, but may also appear in deep areas of the brain; subependymal nodules, which form in the walls of the ventricles the fluid filled cavities of the brain; giant-cell astrocytomas, a type of tumor that can grow and block the flow of fluids within the brain. Cardiac rhabdomyomas are tumors found in the heart of infants and young children. Phakomas are benign tumors found in the eyes, appearing as white patches on the retina. A wide variety of skin abnormalities can occur such as: hypomelanic macules, which are white or lighter patches of skin appearing anywhere; facial angiofibromas also called adenoma sebaceum, which appear on the face and consist of blood vessels and fibrous tissue; forehead plaques, which are common; shagreen patches, usually found on the lower back or the neck; ungula or subungual fibromas that grow around the toenails and fingernails. It’s known that children with TS are a higher risk for several different behavioral problems. The most sever is probably autistic disorder, which usually starts by 36 months and often succeeds early onset seizures. In the preschool years another problem that arises is attention-deficit/hyperactivity disorder (ADHD). During adolescence depression, anxiety appears as they try to deal with new demands of maturing and continuing difficulties of chronic medical problems. If medications are given to treat behavioral problems, parents need to be aware of the effects they will have in a child who may have cardiac rhabdomyomas, renal angiomyoplomas or polycystic kidneys, cortical tubers, subependymal nodules. The child with rhabdomyomy may have disturbance in the cardiac rhyme including increased heart rate, complete heart block, junctional ectopic beats, and Wolf-Parkinson-White syndrome. With seizures certain drugs can lower the threshold leading to new seizures; breakthrough of se izures in a child who had controlled; or an increased number of seizures in a child with chronic epilepsy. Renal damage from medication is not likely in most drugs used for behavior. Topiramate has caused renal stones in 1-2% of patients. Lithium and carbamazepine can cause a change in the ability of the kidney to concentrate urine. As in other medical problems it is always best to reach what you are taking before taking it. There is no cure TSC, although there are a number of treatments for the symptoms. Because TSC is a life long condition, individuals need to regularly monitor by a doctor the best treatments possible. I think children probably suffer the most having to grow up with chronic medical condition with other kids always making fun of you has to really tough on them. However these types of kids are very loving and don’t take much for granted not much of a pay off, but a good one. With the right medication and treatment plans people with TSC might be able to live comfortably. Research is being done to understand the disorder by learning more the TSC1 and the TSC2 genes and the function of the proteins –tuberin and hamartin produced by these genes. Scientists hope knowledge gained from their current research will improve the genetic test for TSC and lead to new avenues of treatment, methods of prevention, and ultimately a cure. tsalliance.org http;//www.ninds.nih.gov rare disease.org Tuberous Sclerosis Alliance fact sheet Hyman MH, Whittemore VH. National Institutes of Health consensus conference: tuberous sclerosis complex. Arch Neurol. 2000 May;57(5):662-5. Review. No abstract available. PubMed citation Lewis JC, Thomas HV, Murphy KC, Sampson JR. Genotype and psychological phenotype in tuberous sclerosis. J Med Genet. 2004 Mar;41(3):203-7. No abstract available. PubMed citation Maria BL, Deidrick KM, Roach ES, Gutmann DH. Tuberous sclerosis complex: pathogenesis, diagnosis, strategies, therapies, and future research directions. J Child Neurol. 2004 Sep;19(9):632-42. No abstract available. PubMed citation Narayanan V. Tuberous sclerosis complex: genetics to pathogenesis. Pediatr Neurol. 2003 Nov;29(5):404-9. Review. PubMed citation Roach ES, Sparagana SP. Diagnosis of tuberous sclerosis complex. J Child Neurol. 2004 Sep;19(9):643-9. Review. PubMed citation Rose VM. Neurocutaneous syndromes. Mo Med. 2004 Mar-Apr;101(2):112-6. Review. PubMed citation Research Papers on Tuberous Sclerosis Complex (TSC)Genetic EngineeringMarketing of Lifeboy Soap A Unilever ProductEffects of Television Violence on ChildrenAssess the importance of Nationalism 1815-1850 EuropeBionic Assembly System: A New Concept of SelfInfluences of Socio-Economic Status of Married MalesThree Concepts of PsychodynamicResearch Process Part OneIncorporating Risk and Uncertainty Factor in CapitalOpen Architechture a white paper

End of Module Project Assignment Example | Topics and Well Written Essays - 1750 words

End of Module Project - Assignment Example In 2012, Sony reported a massive loss of 67 billion Yen (Hirai 2012). In 2011, the company reported an even larger loss of 200 billion Yen. Sony is not keeping up the proper pace of innovation in the smartphone industry and with other consumer electronics, allowing companies such as Samsung to seize more market share and gain a reputation for pioneering product development with many different target consumer segments. If Samsung fails to innovate, it will continue to report massive losses and difficulty in recapturing its once-heralded reputation in innovation. Sharp, a major competitor associated with consumer television products, recognises the demand for technological change in its many international markets. Sharp, as a result, recognised that main competition in this industry were not effectively developing 3D television technologies and determined that significant capital investment in R&D would assist in allowing Sharp to capitalise on this innovation. Sharp reported revenues of $24 billion USD in 2011 as a result of 3D television innovations (Sharp 2013). Furthermore, another main competitor, Sharp, is also adept at exploiting technological change in the market in order to pioneer many different consumer electronics products. Sharp recognised that its competitors were not capitalising on 3D television technology and devoted considerable R&D-related resources on this emerging technology. As a result, this firm achieved revenues of nearly 24 billion USD in 2011 (Sharp 2013). Microsoft, the producer of the pioneering gaming console, Xbox, also continues to be a competitive, innovation-focused market threat for Sony. With each new version of the Sony Playstation, the first real innovation for Sony in well over two decades, Microsoft times its launches of its own innovative changes to the Xbox, serving as a brand threat for the Sony Corporation. Furthermore, Microsoft has begun an acquisition strategy to

IT Development And Strategy Essay Example | Topics and Well Written Essays - 1250 words

IT Development And Strategy - Essay Example Describe ways of managing the transition in the support, turnaround, factory, and strategic quadrants? Transitions in the role of IT are crucial to enabling organizations to evolve in their reliance on IT for sustainable business processes. Various factors that are derived from within the environment or outside promote the assimilation of IT with business processes for greater efficiency, etc, thereby prompting the transformation in the role from support to turnaround to the factory and to strategic quadrant. Usually, these triggers are received from the environment and the changing trends in time, which also explains why several firms solely relying on IT for support services began incorporating IT to provide other services to their global consumers. A shift to the turnaround quadrant is often characterized by a need to identify IT as an opportunity in order to usefully utilize insightful data analytics to change strategies thereby gaining an advantage. Organizations that base heavi ly on their factory processes also find IT integration quite helpful in helping them optimize their uptimes. By doing so, they try to circumvent serious downtimes, of which even the slightest, costs a huge amount to any particular organizations (Applegate, Austin, Soule 2009, p. 427). That is why organizations use IT systems in order to prevent significant downtimes to keep their factory operations running smoothly and efficiently. This demonstrates a shift from turnaround to factory quadrant.